In 2008, gastroenterologist Colleen Kelly had a patient with a recurring and debilitating infection of the gut with a microbe called Clostridioides difficile. Nothing Kelly did could ease the woman’s severe abdominal cramping and diarrhea.
So Kelly — at her patient’s urging — decided to try something highly experimental: transplanting a fecal sample from a healthy donor into the large intestine. And it worked.
Kelly, of Brown University School of Me